HPU – one cause, multiple symptoms

High values – strong symptoms

If an HPU test is positive, the metabolic disorder is basically present. However, the test value says nothing about the type and severity of the symptoms.

The discoverer of HPU, Dr. John Kamsteeg, associates high concentrations of the HPL complex, which is measured in the HPU test, with severe symptoms. In his book “HPU and then” he writes: “If there is a very high concentration of the HPL complex in the urine (over 2.5 µmol per litre), then this usually means a worsening of the symptoms”.
Not only the loss of micronutrients due to the excretion of the defective heme causes symptoms, but also the accumulation of pyrroles in the body. If the pyrroles are deposited in the muscles, this can lead to pain in the limbs and joints (so-called fibromyalgia).

Wide symptom range

Since haem is involved in over 300 enzymatic reactions in human metabolism, HPU can cause a wide range of symptoms. Especially in cases of increased stress (psychological stress, unbalanced nutrition, injuries, leaky gut, infections, toxic stress…), the body excretes more and more defective haem via the urine.

Since the body attaches zinc and vitamin B6 (to a lesser extent also manganese) to the defective haem in order to be able to excrete it via the kidneys, these micronutrients are missing in the body. Depending on where in the metabolism a deficit develops, different symptoms occur in HPU patients. Among the most frequent are:

  • General state of health
  • thyroid gland
  • gastrointestinal
  • uro-genital area
  • skin
  • Teeth and bones

The symptoms can vary in their appearance and vary greatly in their severity.

Zinc and vitamin B6 deficiency and its (possible) consequences

Most patients suffer from zinc deficiency due to the zinc-bound elimination of the HPL complex. This often leads to frequent, sometimes even chronic infections (e.g. of the paranasal sinuses). These in turn consume large amounts of iron.

Thyroid gland and adrenal insufficiency

The body also needs vitamin B6 to produce vitamin B3 (niacinamide), which in turn is involved in the production of thyroid hormones. (Thyroid problems often occur in HPU patients).

Thyroid hormones are central regulators of numerous metabolic processes as well as digestion. A disturbance of the thyroid hormones is usually accompanied by a disturbed digestion. If food intolerances arise due to a disturbed intestinal barrier, the immune system is constantly on alert due to systemic inflammatory reactions. The constant heroin under-regulation of the immune system by cortisol in turn weakens the adrenal glands.


The hormones of the adrenal gland and the thyroid gland give the body strength and endurance. Both are interdependent and try to compensate for weaknesses in each other’s organs. However, this can quickly overload the still well-functioning organ and lead to exhaustion phases or even a total burnout in the HPU patient.

HPU and the Psyche

Constant or recurring states of exhaustion lead to the fact that most HPUlers do not classify themselves as physically and psychologically resilient. Due to the chronic deficiency of the micronutrients zinc, vitamin B6, magnesium and manganese, the neurotransmitters also lose their balance. Because for their production the appropriate micro nutrients are compellingly needed.

Noradrenalin controls the attention. For its synthesis the body needs manganese, vitamin B6 and zinc.

Serotonin controls impulse control, positive mood and the feeling of satiety. For its synthesis the body needs zinc, magnesium and vitamin B6.

Dopamine controls the drive. For its synthesis the body needs manganese and vitamin B6.

Fears are a frequent companion of the HPUler. On the one hand, they are caused by micronutrient deficiencies and the resulting disturbed synthesis pathways of the neurotransmitters. On the other hand the fears of the HPUler result from the numerous physical deficits, with which concerned people have to fight. These include allergies, hypoglycaemia, circulatory problems and micronutrient-related hormonal changes.