Irritable colon with HPU

Irritable colon and Leaky Gut

“Many people with HPU have stomach and/or intestinal problems”, writes Dr. J. Kamsteeg in his book “HPU und dann?”. The statement is based on the evaluation of questionnaires from about 5,300 people with HPU detected by Keac.

Poor protein digestion

Characteristic are flatulence, diarrhoea, constipation and pain – the irritable bowel syndrome. This may be due to a disturbed protein digestion caused by a deficiency of zinc and manganese. Many of the protein-splitting enzymes in the intestines (peptidases) are dependent on these two minerals as cofactors. Only with their help they can break down proteins from fish and meat into individual amino acids.

Fructose Intolerance

An intolerance to fructose can also lead to digestive problems. Further information on fructose intolerance in HPU can be found here.

Food intolerances

“More than 80% of HPU patients are food intolerant.”

Alternative practitioner Dr. Tina Maria Ritter and specialist for psychotherapeutic medicine, Dr. Luitgard Baumeister-Jesch, in her book “Metabolic Disorder HPU” (VAK Verlags GmbH). 

As a result, this often leads to faulty fermentation processes and shifts in the intestinal flora balance.

Reasons for food intolerances

The intestinal mucosa is also dependent on micronutrients such as zinc and vitamin B6. A lack of these micronutrients for many years can lead to a leaky gut and chronic inflammatory processes.

Leaky Gut and Inflammatory Reactions

A Leaky Gut arises when the tight junctions, the sluices of the intestine, no longer function properly. The tight junctions are located between the mucosa cells of the intestinal mucosa. Among other things, they are controlled by the nervous system. In the healthy intestine, tight junctions selectively allow only those substances that the body needs to pass through the intestinal wall into the interior of the body. These include, for example, certain food components, water, electrolytes and ions.

If the tight junctions are no longer able to open only when needed due to micronutrient deficiencies, dysbiosis or toxin exposure (including alcohol and medication), food components, bacterial toxins and other toxins can constantly enter the body through the intestinal wall unhindered. This is referred to as increased intestinal permeability.

This influx overloads the liver and leads to immune reactions. The body reacts to the indiscriminately inflowing substances with a local and systemic chronic inflammation, which in turn can increase the intolerance of numerous foods.

Detection of a Leaky Gut

A Leaky Gut can be diagnosed by a stool sample. Zonulin and alpha-1-antitrypsin are measured. They are regarded as permeability markers of the intestinal mucosa. If these parameters are increased, there is a Leaky Gut. Zonulin can also be determined in blood serum.

The most common food intolerances in HPU 

The immune system most frequently reacts to milk protein, grain and egg. By not eating these foods, those affected can usually alleviate their symptoms.

Food intolerances are not real IgE-mediated allergies, where the symptoms occur immediately after eating the food in question and can trigger an allergic shock in severe cases. Food intolerances can occur up to 72 hours after consumption of the food and manifest themselves in abdominal pain, diarrhoea, flatulence, but also in skin reactions, mood swings, etc.

Detection of food intolerances

Food intolerances are measured, for example, using an IgG test. Depending on the number of foods tested, such a test can be quite expensive, but is of great benefit to the HPU patient. Until the HPU tornve metabolism normalizes and the healing of a possibly existing Leaky Gut is complete, the HPUler can purposefully do without incompatible foods. In this way the allergy readiness of the body is interrupted, the intestine can recover and silent inflammatory reactions subside.