Haem deficiency slows down detoxification phase I
HPU leads to a lack of haem. Haem, in turn, is an important component of cytochrome P450 enzymes – an important group of Phase I detoxification enzymes. The lack of cytochrome P450 can slow down phase I detoxification.
Other detoxification enzymes also rely on haem. These include:
- the nitrogen monoxide synthase (NOS),
- the sulfite reductase and others.
If the detoxification reactions do not take place to a sufficient extent, oxidative stress in the body increases, as free radicals are not degraded and continue to damage the cells.
Vicious circle of heavy metal exposure
Due to its poor detoxification capacity, the HPU patient builds up heavy metals and other toxic substances in the body. Mercury, Lead, Cadmium and Aluminium are already known to have a Porphyria-promoting effect. The HPL complex formed in the patient’s with HPU is also a pyrrole, the formation of which is favoured by these substances.
Cadmium, Cobalt, Copper, Lead, Mercury and Nickel inhibit the absorption of Zinc. A lack of Zinc (see above) in turn has a negative effect on the detoxification machinery. The same applies to the HPU-related lack of Gluthation. The detoxification system is also considerably affected by this.
Am I contaminated with heavy metals?
Heavy metal contamination can be the reason for unsatisfactory therapy results, so-called therapy blockages. It is therefore important to check whether there is excessive exposure to heavy metals or toxic metals (aluminium belongs to the light metals from a chemical point of view).
Schwermetallbelastungen können der Grund für nicht zufriedenstellende Therapieergebnisse, sog. Therapieblockaden sein. Daher ist es wichtig zu prüfen, ob eine übermäßige Belastung mit Schwermetallen bzw. toxischen Metallen (Aluminium gehört rein chemisch betrachtet zu den Leichtmetallen) vorliegt.
The blood and hair analysis
Heavy metal contamination can only be detected by blood analysis if the heavy metals have just been absorbed. However, it is not possible to detect exposures that have taken place in the past in this way. This is because toxic metals are stored in fatty tissue.
Heavy metals can also only be detected in the hair if the absorption or release of these substances has only just occurred.