Detoxification in case of HPU

The body constantly detoxifies

External toxins and metabolic products of the body can have a damaging effect on enzymes or DNA if they are not eliminated. The body therefore has to detoxify not only when it has had contact with toxins. Detoxification is a natural process that takes place continuously.

Enzymes and micronutrients – Engines of detoxification

For detoxification, the body needs enzymes and lots of micronutrients. The most important detoxification organs (skin, lungs, liver, kidneys and intestines) have therefore numerous detoxification enzymes. A complete detoxification of the human body is not possible, as metabolic products are constantly produced which the body has to eliminate. However, the need for micronutrients for detoxification increases with the “amount of toxins” in the body. If external toxins are added to internal metabolic products (e.g. through amalgam fillings, polluted air or chemicals in food or cosmetics), this can lead to a deficiency of B vitamins, Zinc, Selenium and Glycine, as these substances are then absorbed in larger quantities by the detoxification system.

Detoxification in the case of HPU

Detoxification is one of the central elements of HPU therapy. There is a very simple explanation for this: HPU patients are bad detoxifiers. Over time, they accumulate heavy metals and other substances to be detoxified in their body, which in turn influence other metabolic mechanisms.

Micronutrient deficits slow down the detoxification machinery

Patients suffering from HPU are mainly lacking vitamin B6, zinc and manganese. This has the following effects on the body’s own detoxification system:

Vitamin B6 deficiency:

  • disturbs the synthesis of the sulphurous amino acids needed for detoxification, as each amino acid is produced by special transaminases that require P5P (the activated vitamin B6) as a cofactor.
  • Amino acids are broken down into ammonia, which must be rapidly degraded further. The enzymes involved also need P5P as a cofactor for this. Without P5P the toxic ammonia remains in the body.
  • The amino acid glutamine is needed for purine and glutathione synthesis. Both synthesis steps rely on P5P.
  • The detoxifying enzyme cytochrome P450 (CYP 450) contains a haem group. This means that this synthesis is also inhibited in cases of P5P deficiency.

Zinc deficiency:

  • directly blocks the detoxification of heavy metals
  • reduces the transformation of vitamin B6 into P5Pblockiert direkt die Entgiftung von Schwermetallen

Manganese deficiency:

  • Manganese is a co-factor of essential detoxification enzymes such as mitochondrial superoxide dismutase (SOD)
    Haem deficiency inhibits detoxification phase I

Haem deficiency slows down detoxification phase I

HPU leads to a lack of haem. Haem, in turn, is an important component of cytochrome P450 enzymes – an important group of Phase I detoxification enzymes. The lack of cytochrome P450 can slow down phase I detoxification.

Other detoxification enzymes also rely on haem. These include:

  • catalases,
  • Pyrrolases,
  • the nitrogen monoxide synthase (NOS),
  • the sulfite reductase and others.

If the detoxification reactions do not take place to a sufficient extent, oxidative stress in the body increases, as free radicals are not degraded and continue to damage the cells.

Vicious circle of heavy metal exposure

Due to its poor detoxification capacity, the HPU patient builds up heavy metals and other toxic substances in the body. Mercury, Lead, Cadmium and Aluminium are already known to have a Porphyria-promoting effect. The HPL complex formed in the patient’s with HPU is also a pyrrole, the formation of which is favoured by these substances.

Cadmium, Cobalt, Copper, Lead, Mercury and Nickel inhibit the absorption of Zinc. A lack of Zinc (see above) in turn has a negative effect on the detoxification machinery. The same applies to the HPU-related lack of Gluthation. The detoxification system is also considerably affected by this.

Am I contaminated with heavy metals?

Heavy metal contamination can be the reason for unsatisfactory therapy results, so-called therapy blockages. It is therefore important to check whether there is excessive exposure to heavy metals or toxic metals (aluminium belongs to the light metals from a chemical point of view).

Schwermetallbelastungen können der Grund für nicht zufriedenstellende Therapieergebnisse, sog. Therapieblockaden sein. Daher ist es wichtig zu prüfen, ob eine übermäßige Belastung mit Schwermetallen bzw. toxischen Metallen (Aluminium gehört rein chemisch betrachtet zu den Leichtmetallen) vorliegt.

The blood and hair analysis

Heavy metal contamination can only be detected by blood analysis if the heavy metals have just been absorbed. However, it is not possible to detect exposures that have taken place in the past in this way. This is because toxic metals are stored in fatty tissue.

Heavy metals can also only be detected in the hair if the absorption or release of these substances has only just occurred.

The heavy metal provocation test (chelate test)

The detection of chronic heavy metal poisoning is only possible with a provocation test. In this test two urine samples of the patient are compared. First the patient collects the first morning urine.

Note: The pH value of the morning urine is important! It should definitely be in the alkaline range (< pH 7), as heavy metals are deposited in the kidney in the acidic environment instead of being excreted via the kidney. If the morning urine is in the acidic pH range, a basic infusion is administered before chelation.

Then the patient receives infusions or capsules with metal-binding substances (chelating agents). DMSA (dimercaptosuccinic acid), DMPS (dimercaptopropanesulfonic acid) and EDTA (ethylenediaminteracetic acid) are usually used here.

These chelating agents bind the metals and are then excreted again via the kidneys. After 1-2 hours the patient gives the second urine sample. Both urine samples are evaluated and compared in a laboratory. Between 30 and 35 heavy metals are analysed.
The metals that occur in the urine after chelating in comparison to normal urine, or are excreted much more than before, usually represent a burden for the patient.

Based on the type of toxic substances excreted and the quantity, the therapist draws up a plan for detoxification of the body from the basis of chelation therapy. The heavy metal provocation test provides the basis for monitoring the elimination results both during the course and at the end of the therapy.

Dr. med. Dipl.-Med. Thomas B. Fischer, President of the Medical Society for Clinical Metal Toxicology, on this subject:

“This diagnostic method has been developed by consensus of international (IBCMT) and German (KMT) medical societies. It is not a so-called “alternative treatment method” and not a “special therapeutic direction”, but the only scientifically recognized, practical diagnostic method worldwide for the detection of chronic heavy metal contamination.”

Further detoxification measures for HPU

Taking the “typical” HPU supplements ( Zinc, Manganese, Activated Vitamin B6 (P5P) and Magnesium) not only helps significantly to support the body’s detoxification machinery, it is also a prerequisite for further detoxification measures.

Depending on the severity of the toxic load, additional detoxification measures can be helpful.

Fresh water algae Chlorella

The freshwater alga chlorella is used in detoxification therapy to bind heavy metals (e.g. Mercury from Amalagam). In addition to plant-based active ingredients, it contains a number of micronutrients that support the detoxification-weak HPU metabolism. As chlorella itself can be contaminated with heavy metals, it is essential to check the manufacturer’s certificate of analysis when buying it.

Caution: Not all HPU users tolerate detoxification therapy with chlorella. With the high-dose intake of approx. 20 g per day, the body absorbs a very large amount of chlorophyll, which can lead to complications such as a severe physical and/or mental drop in performance.

Detoxification systems overloaded

Chlorophyll and haem are similar in structure and are possibly degraded by the same metabolic pathways. If the body has now formed a lot of misfolded haem and also absorbs an unnatural amount of chlorophyll, this degradation pathway could be overloaded and lead to side effects of Chlorella therapy.

In HPU patients, detoxification phase I is often disturbed. A further possible overload of the detoxification performance could occur if chlorella toxins such as Lead and Mercury have to be rapidly mobilised and these substances have to be excreted at the same time as the misgrafted Haem.

“Whether the Haem metabolism is already loaded to the limit and thus a therapeutic use of chlorophyll is indicated or contraindicated, can be determined by the pyrrole values in the urine (haemopyrrollactam).”

Gerald Würkner, environment medicine society 2014; 27(4): 277-285

Excessive copper

Chlorella contains copper as well as other micronutrients, which can put additional stress on the metabolism of the HPUler especially at the beginning of the therapy ( Copper is an antagonist of zinc, which is often deficient in HPU patients).

Gene mutations

Certain gene mutations such as CBS and SUOX could reduce the usability of Sulphur (as in Chlorella) and ensure that taking Chlorella is associated with side effects. A genetic test provides information about this.

Draining HPU infusions

In addition to vitamin B6, Zinc and Manganese, other micronutrient substances also play an important role in detoxification. Regular blood checks (about 2 to 4 per year) provide information about deficiencies, which should subsequently be balanced by orally administered micronutrients or even infusions.

Detoxification through Chelation therapy

Chelation therapies with chelating agents are an effective method to get rid of toxic metals. Chelating agents are substances that can bind metals particularly well and in large numbers. The most commonly used chelating agents are EDTA, DMPS and DMSA.

EDTA preferentially binds metals with an affinity for oxygen, such as Lead and Aluminium, but also Iron. DMPS and DMAS preferably bind sulphur-affine metals such as Mercury and Arsenic.

Chelation therapy belongs in the hands of a therapist, as improper use of the chelating agents can lead to repoisoning and even kidney failure. In addition, a comprehensive blood count with kidney and liver values, the state of minerals in whole blood and vitamins should be carried out before starting therapy. Protein deficiency states, blood sedimentation, CRP, thyroid gland values and HCY also provide information about the patient’s condition, deficiency symptoms and diseases.

During the therapy, the micronutrient status of the patient should be checked at regular intervals, as useful micronutrients always bind to the chelating agents during chelation therapy and are thus lost. The mineral status should be checked before and during the chelation therapy. In case of deficiencies, these should first be eliminated before chelation therapy is continued.

Chelation therapy – not for these pre-existing conditions

A chelation therapy with chelating agents is not the appropriate method of choice for every patient to eliminate toxic substances from the body. Under the following circumstances, chelation therapy should be avoided due to the expected side effects:

  • Anemia, leukopenia
  • acute infections or inflammations
  • Pregnancy
  • Iron deficiency
  • Mineral deficiency
  • acute pancreatitis
  • acute hepatitis
  • Cachexia (high weight loss)
  • Protein deficiency
  • MS, ALS (here EDTA can trigger thrusts)
  • Heart failure
  • strong cardiac dysrhythmias
  • severe renal dysfunction (creatinine > 2.0, cystatin C > 1.5)
  • Liver dysfunctions
  • Lungs Tuberculosis
  • distinct aneurysm