(Initial) side effects and their causes
In principle, it has proven to be a good idea to slowly increase the dosage of all micronutrients – in other words, to creep in. Initial side effects such as headaches, nausea or vomiting indicate that the initial dosage is too high.
Dr. Kamsteeg explains the phenomenon in his book “HPU and then” with the readjustment of the hormone cycle. The TSH level, which is usually very low at the beginning of HPU treatment, increases with the intake of HPU supplements. At the same time, an increase in serum gastrin is also observed. The resulting increased production of gastric acid can lead to nausea and vomiting.
Countermeasures: Do not take HPU supplements on an empty stomach. Increase the dose slowly over a period of about 3 weeks.
Intolerance of P5P (active form of vitamin B6)
HPU patients often have a disorder of detoxification phase I. If this phase of detoxification is made possible again to a greater extent by supplementation of vitamin B6 and Zinc, more intermediate products are produced, which must be further metabolised in detoxification phase II. However, if detoxification phase II is also compromised (e.g. the function of glutathione S-transferase), the intermediates of detoxification phase I cannot be further processed. As a result, side effects such as nausea, exhaustion or intensification of the HPU symptoms occur when taking P5P. In this case, detoxification phase II should first be improved.
Complementary micronutrients for HPU patients
Since a deficiency of other B vitamins can occur if P5P alone is taken, it is recommended to supplement HPU micronutrient therapy with an activated vitamin B complex.
HPU patients often have a higher copper concentration in relation to Zinc. Therefore, a copper-free multi-mineral preparation can be useful, especially at the beginning of HPU therapy. Copper is considered to be the antagonist of Zinc and can prevent the often empty Zinc reserves from being filled up at the beginning of the HPU therapy.
Determining the level of Copper is not easy, as it is present in the body in bound and in free condition. Free Copper can promote inflammatory processes in the body, which in turn increase oxidative stress in the body. Free Copper should therefore not be present in excess.
The copper level in whole blood does not say anything about the ratio of free Copper to bound Copper. For this purpose, the concentration of the copper-binding protein Ceruloplasmin in the blood must be determined and the concentration of Copper in the blood serum (Copper is present in the serum at about 60% and in the cell at about 40%). Using these two values, the laboratory can calculate the ratio of free copper to bound copper.
If the supplementation of copper is necessary, a time-delayed intake of copper in a ratio of 1:10 to zinc is recommended. (e.g. 2 mg copper, with 20 mg zinc intake).
Q10 (as ubiquinol) rapidly provides many HPU patients with more energy. Coenzyme Q10 is required by numerous enzymes as a cofactor and also plays a central role in the respiratory chain of the mitochodria, the body’s energy suppliers.
Patients with HPU have difficulty storing vitamin D in the liver due to mitochondrial dysfunction. The reason for this is an insufficient supply of cytochrome P-450 monoxygenases. These are the enzymes that store vitamin D in the liver.
Free copper can also combine with vitamin D3 to form complexes and thus lower the vitamin D level.