Causes of HPU

Genetic predisposition

Since HPU occurs in large numbers in many families, it is assumed that the metabolic disorder has a hereditary component. However, one or more genes that can be assigned to the defective haem metabolism have not yet been identified.

HPU is currently not causally curable. With a well-adjusted therapy and an adaptation of the lifestyle, those affected can live almost symptom-free.

Is there an acquired form of HPU?

Whether an HPU can also be acquired in the course of life has not yet been conclusively clarified. Dr. Bodo Kuklinski, a physician for internal and environmental medicine and mitochondrial expert, has found a connection between cervical spine trauma and increased pyrrole excretion.
Furthermore, Dr. Kuklinski was able to show that patients with cervical spine trauma usually have a zinc and vitamin B6 deficiency. Whether a cervical spine trauma is causally involved in the development of HPU or merely intensifies the existing symptoms of HPU remains to be seen.

Cervical spine injury as a possible HPU cause

To suffer a cervical trauma, there is no need for a serious accident. Due to its finely branched nerve branches, the neck joint of the human body is a very sensitive region that is connected to almost all organs. If we spend a long time in front of a computer screen or on a smartphone, the neck joint is particularly strained.
Since Dr. Kuklinski was able to reduce the pyrrole concentration of his patients to normal values after a stiffening operation of the cervical spine, he assumes that this form of HPU must have been acquired.
The mechanism of disease development is based on a chronically increased nitric oxide (NO) concentration. This gas can be released more frequently in cervical trauma and can severely disrupt the function of the mitochondria. NO inhibits the complexes I and III of the respiratory chain and the enzyme aconitase in the citrate cycle of the mitochondria. As a result, the energy production of the mitochondria is restricted and the formation of haem is disturbed. These processes are noticeable in exhaustion and chronic fatigue, as well as in the already known pyrrole excretion with the urine.