HPU and KPU are both disorders of heme metabolism, but not identical. Kamsteeg, for example, describes: “42 percent of people with HPU have (anti-TPO) antibodies in their blood against the thyroid gland. This high percentage is not found in KPU.
Why a KPU test does not diagnose HPU
HPU and KPU (cryptopyrroluria) are similar but not identical. In both metabolic disorders, pyrroles are excreted, which the body incorrectly assembles due to enzymatic weaknesses and then has to excrete due to their toxic effect. KPU excretes 2,4-dimethyl-3-ethylpyrrole (cryptopyrrole), HPU excretes 5-hydroxy-hemopyrrollactam-zinc chelate complex (HPL).
The KPU was already discovered in the 1960s – HPU only 40 years later. The KPU test is carried out quite unspecifically with the Ehrlich reagent and is always positive when there are pyrroles in the urine. This can also be the case, for example, after taking certain drugs or after exposure to toxins. Dysbioses in the intestine can also lead to the excretion of pyrroles.
HPU detection, on the other hand, is much more accurate. It only detects HPL, which is exclusively associated with HPU.
A high-dose micronutrient therapy over a longer period of time should only be considered in the case of a positive HPU test.