Constantly tired and exhausted
Do I have HPU?
Constantly tired and exhausted?
Despite getting enough sleep, you feel exhausted, struggle through the day and feel like you’re never really productive?
Tens of health construction sites at the same time?
Do you frequently suffer from infections, muscle and joint pain, or struggle with migraine attacks? Perhaps your body is becoming increasingly sensitive to certain foods, your skin is causing problems, or your hormones are out of whack?
From doctor to doctor – and still no answers?
Then the metabolic disorder HPU could be the underlying cause.
But there is a solution. You can learn to optimally support your body and feel more energy, clarity, and well-being again. I will show you how.
Am I affected?
HPU stands for Hemo-Pyrrollactam-Uria and refers to a metabolic disorder. The heme metabolism is impaired.
Symptoms of HPU
Low stress tolerance / exhaustion
Anxiety / depression
Susceptibility to infections
Irritable bowel syndrome / food intolerances
Autoimmune diseases / allergies
Skin problems
Histamine intolerance
Migraine
Thyroid disorders (Hashimoto's thyroiditis, Graves' disease)
Cycle disorders / polycystic ovary syndrome (PCOS, newly PMOS)
Muscle and joint pain (fibromyalgia)
Wer bin ich?
Like many other HPUers, I also have just such a decades-long medical odyssey behind me.
I am Sonja Schmitzer, engineer for molecular biotechnology and the person behind HPUandYou®.s
Your support for an active life despite HPU
Get fit despite HPU!
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More Information
What goes wrong with HPU?
In HPU, the enzymes that produce heme in the body do not work properly. In most HPU patients, 3 to 4 out of 8 heme-producing enzymes are impaired in their performance. As a result, the body partially produces incorrectly folded heme, which cannot function properly due to its faulty structure. The following suffer from this:
The oxygen supply to the organs via the blood
The energy production of the cells
The oxygen supply to the muscles
The detoxification.
HPU patients also possess correctly folded heme, otherwise they would not be viable at all. However, the fact that the body cannot properly build a portion of the heme has further consequences:
Loss of vital nutrients
The precursors of the incorrectly folded heme are toxic to the body. In order to excrete these substances more effectively, the body binds them to vitamin B6, zinc, and partly also to manganese. This makes the complex water-soluble, and the substances can be excreted through the kidneys and urine. During this process, the body loses these vital nutrients.
Since vitamin B6 and zinc are co-factors for over 300 human enzymes, it quickly becomes clear that a deficiency in these vital nutrients can lead to a wide variety of symptoms. Manganese is also required for an important enzyme: superoxide dismutase (SOD) in the mitochondria. It protects the mitochondria from free radicals and has a detoxifying effect.
Why am I so tired?
When heme is not built correctly
Heme is one of the substances that is needed in many places in the human body. Most people have already heard of heme in connection with red blood cells – hemoglobin.
Oxygen supply to organs via the blood
Hemeoglobin transports oxygen through our body. It consists of a heme molecule in the center, surrounded by a protein structure. Heme takes on the active role in this structure, as it directly binds the oxygen molecules. Defective heme cannot bind oxygen properly. As a result, the body can absorb less oxygen.
Oxygen supply to the muscles
Heme also occurs in the muscles of the human body (in myoglobin). Here too, it binds oxygen and supplies the musculature with it. In the case of heme damaged by HPU, the muscles are not sufficiently supplied with oxygen – they fatigue quickly.
Energy production in the cells
In the mitochondria, the so-called cell powerhouses, heme also plays a central role. The main task of the mitochondria is the production of energy in the form of ATP (adenosine triphosphate) – the universal energy carrier for all cells. This occurs via the respiratory chain. The respiratory chain consists of a series of heme-containing enzymes, which are located in the inner mitochondrial membrane.
Detoxification
In the body’s own detoxification phase I, heme is an important component of enzymes. These detoxification enzymes ensure, among other things, the breakdown of alcohol, medication, and toxic metals. If the detoxification enzymes in the body are throttled due to HPU, oxidative stress increases. As a result, free radicals can constantly attack the cells.
Metabolism of nerve neurotransmitters
The body also requires heme for the metabolism of tryptophan, serotonin, and melatonin.
Production of important substances
The body needs heme to produce cholesterol, steroid hormones, thyroid hormones, vitamin D, and bile acids.
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Disclaimer and general note on medical topics:
The contents presented here serve exclusively for neutral information and general further education. The texts do not claim to be complete, nor can the timeliness, correctness, and balance of the presented information be guaranteed. The texts in no way replace professional advice from a doctor or pharmacist, and they must not be used as a basis for independent diagnosis and the start, modification, or termination of a treatment for diseases. Always consult your trusted doctor regarding health questions or complaints! I assume no liability for inconveniences or damages resulting from the application of the information presented here.